21 May, 2012 (updated 10 minutes ago).
| Type | Public |
|---|---|
| Traded as | OTCQB: LFVN |
| Industry | Nutrition, Skin Care products |
| Founded | 2003 |
| Headquarters | Salt Lake City, Utah, United States |
| Area served | United States, Canada, Japan, Mexico, Australia |
| Key people | Douglas C. Robinson, David W. Brown, Kirby Zenger, Carrie McQueen, Joe M. McCord |
| Products | Protandim, TrueScience |
| Revenue |  US$ 70.38 million (Dec 2011)[1] |
| Operating income | US$ 11.61 million (Dec 2011)[2] |
| Website | LifeVantage.com |
Protandim is a patented dietary supplement marketed by LifeVantage Corporation (OTCQB: LFVN; formerly LifeLine Therapeutics and Yaak River Resources, Inc), a Utah-based multilevel marketing company.[3] The manufacturers of Protandim claim the product can indirectly increase antioxidant activity by upregulating endogenous antioxidant factors such as the enzymes superoxide dismutase (SOD) and catalase, as well as the tripeptide glutathione by activating a transcription factor Nrf2. Like all dietary supplements, Protandim has not been evaluated by the U.S. Food and Drug Administration (FDA) and "is not intended to diagnose, treat, cure, or prevent any disease."[4]
Contents |
Protandim was invented by Paul R. Myhill and William J. Driscoll.[5] The product was originally produced under a manufacturing agreement with The Chemins Company of Colorado Springs, Colorado.[6] In July 2008, LifeVantage entered into a new manufacturing agreement with Cornerstone Research & Development, Inc. to produce Protandim, and with Wasatch Product Development, LLC to produce True Science skin cream.[7]
The product consists mainly of a blend of 5 ingredients (amounts per caplet listed in parentheses):
Additional ingredients include: calcium, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, modified cellulose, silica, and stearic acid.
According to the manufacturer, the side effects of Protandim may include allergic responses, gastrointestinal disturbances (stomach ache, diarrhea, vomiting), headache, and rash of the hands and feet.[8]
Milk Thistle - The University of Maryland Medical Center suggests milk thistle may react with a variety of medications, including, anti-psychotics, anti-depressants, anti-seizure medications, blood-thinning drugs, anti-cancer agents, and cholesterol-lowering drugs. If you take any of these medications, checking with your doctor before taking Milk Thistle."[9] A 2007 peer reviewed article suggests milk thistle extracts are known to be safe and well tolerated, and toxic or adverse side effects observed in the reviewed clinical trials seem to be minimal.[10]
Nine research studies of Protandim have been published as of 2011; all but two[11][12] were conducted in in vitro or in vivo animal models. Six of the studies were conducted, written, and/or funded in whole or in part by LifeVantage and its predecessor Lifeline Therapeutics.[11][13][14][15][16][12]
Lifevantage advertises Protandim as a Nrf2 activator.[17] A 2003 study showed that Nrf2 and heme oxygenase 1 are induced by low doses of curcumin, (a chemical constituent of turmeric and one of the principal ingredients in Protandim) in isolated kidney epithelial cells.[18]
A 2008 review article noted that Protandim is one of many supplements that claim to act as antioxidants, but that changes in TBARS levels and increases in the levels of antioxidant enzymes in response to a treatment do not provide a reliable indication that the treatment has an antioxidant effect, since the same responses are produced by pro-oxidant compounds that induce oxidative stress. The authors suggested that measurement of isoprostanes might be a better indication of lipid peroxidation and oxidative damage to DNA.[19]
A review by Science-Based Medicine of eight peer-reviewed studies found insufficient evidence to support its usefulness. Dr. Harriet Hall states, "We simply don’t know enough at this point to recommend Protandim for treatment or prevention of any disease, for anti-aging, for making people feel healthier or more energetic, or for anything else."[20]
Two studies of Protandim have been conducted in humans subjects. One of these studies, a non-randomized, non-controlled trial, reported that Protandim increased the levels of the antioxidant enzymes SOD and catalase while reducing TBAR levels.[11][21]
The second study, a double-blinded, randomized, placebo-controlled trial published by McCord and colleagues in 2012, examined the effect of Protandim on pulmonary oxidative stress and alveolar epithelial permeability in 30 recovering alcoholics.[12] Protandim (14 subjects at a dose of 1350 mg/day; double the daily dose recommended by the manufacturer) or placebo (in 16 subjects) were administered for 7 days. Relative to placebo-treatment, Protandim had no significant effects on alveolar epithelial permeability or on oxidative stress, epithelial growth factor, fibroblast growth factor, interleukin-1β, and interleukin-10 levels in bronchoalveolar lavage fluid. Treatment with placebo, however, produced a significant reduction in plasma levels of TBARs, a marker of oxidative stress (i.e., lipid peroxidation).
In studies published by LifeVantage executive Joe McCord and colleagues, it was reported that Protandim increased glutathione levels in isolated cells[13] and that intraperitoneal injection of an alcohol-based extract of Protandim could suppress skin tumor incidence in an experimental model in mice[14][22] and result in suppression of p53 and induction of MnSOD in isolated mouse epidermal cells in vitro.[22]
An in vitro gene expression microarray study published by Dr. McCord and associates in 2011 examined the effect of Protandim on gene expression profiles in human primary vascular endothelial cells and a SK-N-MC human neuroblastoma-derived cell line. Protandim was found to upregulate Nrf-2 and to modulate the expression of a variety of other genes.[23]
Another study conducted by Dr. McCord and associates investigated the effect of intraperitoneal injection of an alcohol-based extract of Protandim in an experimental model of pulmonary hypertension in rats. It was reported that the extract induced myocardial nuclear factor E2-related factor 2 and heme oxygenase 1, prevented a loss of myocardial capillaries, minimized fibrosis and preserved RV function [24]
Other studies by McCord and colleagues have examined the effects of Protandim on fibrosis in a rodent model of Duchenne muscular dystrophy (DMD)[15] and the effects of an alcohol extract of Protandim in an in vitro saphenous vein graft model.[25] In a study investigating the effects of various agents on skeletal muscle tissue function in an in vitro model of DMD, compounds used clinically for DMD treatment, such as the glucocorticoids, were found to produce a potentially beneficial increase in muscular contractile force, while Protandim produced the opposite effect, significantly inhibiting contractile force.[26]
In 2009, LifeVantage was sued by Utah-based Zrii LLC, a marketer of nutritional fruit drinks endorsed by Deepak Chopra, based on allegations that LifeVantage had conspired with former Zrii executives to “ruin the company” and take it over “on the cheap” following a “mass exodus” of Zrii distributors to LifeVantage. The case was closed in December 2009 following LifeVantage’s settlement payment of $400,000 to Zrii.[27]
On October 14, 2011, Burke Hedges, a former high-level LifeVantage distributor, filed a lawsuit with the Utah District Court against LifeVantage and its executives, seeking $3 million in punitive damages over allegations of wrongful termination and tortious interference.[28]
On June 20, 2007, LifeVantage announced that it had entered into a 3-year agreement with TV personality Montel Williams to act as a spokesperson for the company’s products.[29] On September 15, 2011, LifeVantage entered into a similar 2-year agreement with entertainer Donny Osmond, stipulating that the company would pay Osmond for various promotional appearances and video recordings and commissions for sales of LifeVantage products.[30]
bodyhonest.com Protandim is the only supplement clinically proven to reduce oxidative stress by an average 40%, slowing down the cell aging process to the level of a 20 year-old.
protandim lifevantage oxidative stress antioxidant
Since the ABC Primetime special aired 7 yrs ago, featuring Protandim, many more studies of validation have taken place. Watch this 9 min. video to do your due diligence. www.wpbglobal.com
Lifevantage Matt Leavitt Nancy Leavitt fit4excellence.com
NBC Today Show looks at Protandim by LifeVantage, presented by www.lifegenenow.com, a Protandim Distributor
Protandim Health Wellness Anti-Aging
Protandim is an anti-aging breakthrough. Developed after 40 years of research exclusively for LifeVantage and featured on ABC, NBC, PBS, in The Wall Street Journal, and described in CNN Chief Medical Correspondent Dr. Sanjay Guptas book, Chasing Life, Protandim reverses cell aging in your genes.
Protandim lifevantage Dr. mccord
Montel Williams shares his experience using Protandim® more accurately, what he noticed when he was unintentionally off the now scientifically proven herbal product. PROTANDIM® DESTROYS MILLIONS OF FREE-RADICALS PER SECOND Years before Protandim® moved to the direct sales arena of Network Marketing, ABC PRIMETIME LIVE ran this story on the potentially life changing product. Now many of the peer reviewed, published studies are done and there's proof that Protandim® does an amazing job of triggering your DNA inside your cells to produce your own natural antioxidants by your body... for your body. And it's all natural herbs. The unique blend of phytonutrients in Protandim® signal your body's genes to produce special antioxidant enzymes, SOD, CAT (catalase), and Glutathione, that work together as the bodys first line of defense against free radicals. These enzymes are catalytic, which means that SOD, CAT and GSH are not used up when they neutralize free radicals. A single daily caplet of Protandim® creates a cascade of your bodys natural catalytic antioxidants that are able to destroy millions of free radicals per second, on a continuous basis - 24/7. Ron Maurer - LifeVantage Independent Distributor of Protandim® 206.203.2240
Dr. Joe mccord Dr. David Perlmutter truescience skin care anti-aging cream
Here is Donny Osmond on Dr Phil 2/8/2012 and talks about his "secret" to his youthful look. Spoiler alert, his secret is Protandim from Lifevantage
From the company Lifevantage formerly Lifeline Therapeutics who's Protandim product was featured on ABC Primetime
Health Wellness Anti-Aging Vitamins
Cassie is my 8 year old yellow lab who has been diagnosed with hip dysplasia & arthritis for the past couple years. She also tore her ACL on her back right knee in late spring of 2011.
www.AntiAgingTruth.info Incredible opportunity to become involved with the company, LifeVantage, maker of Protandim®. This company is in "pre-launch status". The unique blend of phytonutrients in Protandim® signals your cells to produce powerful antioxidant enzymes, SOD (superoxide dismutase) and CAT (catalase), which work synergistically to neutralize more free radicals than any "consumable" antioxidants. The results of a new peer-reviewed study (Free Radical Biology & Medicine) clearly demonstrate that Protandim® produces a 300 percent increase in glutathione, which is a key antioxidant and anti-aging factor More information is available at www.AntiAgingTruth.info or http
anti aging home-based business
BeyondAntioxidants.com Hear Lisa as she explains what effect Protandim has had on her Multiple Sclerosis, Protandim is a Nrf2 activator and decreased oxidative stress an average of 40%. Free radicals and oxidative stress have been found to be factors in many chronic diseases. For more information on oxidative stress go to pubmed.org.
Multiple sclerosis Protandim health MS Nrf2 activator
8aloha.com Definitions Explained - Nutrigenomics - Protandim is a Nrf2 activator, protein is master regulator - Every gene has a "dimmer" switch, Protandim moves switch up or down - Survival genes encoding, antioxidant genes, anti-inflammatory genes, antifibrosis genes Powerpoint shows cell structure and how Nrf2 activator "works" ------------------------------- At about minute ten (10) 1 Protandim -- Management of Addictive Behaviors -- stop Smoking, cocaine, etc. Haven't been validated in research yet, but has good possibilities with Protandim. Powerpoint shows cell structure and what happens when brain exposed to drugs like nicotine. "how diabolical the mechanism of getting hooked is" Protandim might be useful in reducing longing, research to come 2 New Research on Protandim and Metabolic Syndrome by major scientist in the field, increased risk of heart disease, defined by 4 (any 2 defines syndrome) central obesity,elevated triglycerides, hypertension, fasting plasma glucose 3 Protandim affects PON 1, positively affects heart disease, diabetes, muscular dystrophy
protandim dr joe mccord diabetes heart disease
Protandim is a clinically proven synergy of 5 herbs used in Chinese and ayurvedic medicine that turns on the DNA through a pathway called Nrf2, this dramatically slows the cellular aging process! It turns on hundreds of genes that produce your body's own protective enzymes.
Protandim stop your clock stop my clock Dr. Joe mccord
NOTE: Daily Life Source is looking for distributors to help get the word out about Protandim. If you would like a free and no obligation introduction to this business please contact us. We can do the presentation by phone or SKYPE. Dr. Joe McCord explains the Pubmed.gov study on how Protandim affected skin cancer in mice. For more information please visit www.DailyLifeSource.com. * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
invention protandim Dr. mccord lifevantage
Dr. McCord explains how cocaine and nicotine affect the brain and how Protandim alters their effects.NOTE: Daily Life Source is looking for distributors to help get the word out about Protandim. If you would like a free and no obligation introduction to this business please contact us. We can do the presentation by phone or SKYPE. www.DailyLifeSource.com contact us there. Thanks . * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
invention protandim Dr. mccord lifevantage
Order PROTANDIM at www.undergroundwellness.com ! International orders available! I'm not a big supplement guy, but Protandim is the most legit supplement I have EVER seen or taken. The recovery between workouts is just stupid! Be sure to go to www.pubmed.gov , where you can find SEVEN peer-reviewed published studies on the actual product (not just the ingredients). Harvard. LSU. The Ohio State University. Protandim is PROVEN to reduce oxidative stress by an average of 40 percent! That's HUGE! It boosts your glutathione by 300% Glutathione is essential for muscle recovery and detoxification. Yeah, it's an MLM product, but I don't care. It's just too awesome a product to blow off. There WILL be a day when everyone takes Protandim. I guarantee that! Check it out! LISTEN to our Protandim radio show - http Want Proof that Protandim works? www.undergroundwellness.com Order at www.undergroundwellness.com Catch NEW videos and blogs at www.undergroundwellness.com ! Sign up on the website to receive video notifications. TWEET ME at http ORDER Protandim at www.undergroundwellness.com www.facebook.com www.facebook.com www.blogtalkradio.com
